Carvedilol Solubility Enhancement by Inclusion Complexation and Solid Dispersion: Review

Carvedilol is an effective nonselective alpha-1 and beta blocker discovered by Fritz Wiedemann [1] . It is an antihypertensive drug indicated for the treatment of mild to severe congestive heart failure (CHF), angina pectoris, cardiac arrhythmias and myocardial infarction [2] . Water solubility of Carvedilol is a fundamental property that affects the drug absorption after oral administration. Moreover, its dissolution and gastrointestinal permeability are the parameters that control its bioavailability [3] . The most frequent causes of low oral bioavailability is attributed to poor solubility and low permeability [4] . Carvedilol is categorized as class II drug with low solubility and reasonable membrane permeability.